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The rate of metabolism of donepezil may be increased by medications that increase the amounts of these enzymes, such as carbamazepine tegretol , dexamethasone decadron , phenobarbital, phenytoin dilantin , and rifampin rifadin .

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An acute myopathy has been observed with the use of high doses of corticosteroidsmost often occurring in patients with disorders of neuromuscular transmissione.gmyasthenia gravisor in patients receiving concomitant therapy with neuromuscular blocking drugse.gpancuroniumThis acute myopathy is generalizedmay involve ocular and respiratory musclesand may result in quadriparesisElevation of creatinine kinase may occurClinical improvement or recovery after stopping corticosteroids may require weeks to years.

Acute exacerbations of multiple sclerosiscerebral edema associated with primary or metastatic brain tumorcraniotomyor head injury.

For which conditions is this drug approvedDexamethasone is used in combination with other agents for the treatment of myeloma and lymphomasDexamethasone may also be used to help prevent or reduce nausea and vomitingto reduce swelling and related pressureor as an anti-inflammatory agentIt is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDAPatients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.

Exophthalmosglaucomaincreased intraocular pressureposterior subcapsular cataracts.

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tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antihistamines; anticonvulsants such as carbamazepine tegretol , phenobarbital barbita, luminal, solfoton , and phenytoin dilantin ; dexamethasone decadron, others ; diazepam valium ; diltiazem cardizem, dilacor, tiazac ; erythromycin e.

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